Pair Name	Furanodiene, Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	BAD	hsa572
	Up-regulation	Expression	BAX	hsa581
	Up-regulation	Activity	CASP3	hsa836
	Up-regulation	Activity	CASP7	hsa840
	Up-regulation	Cleavage	CASP9	hsa842
	Down-regulation	Expression	ESR1	hsa2099
	Up-regulation	Cleavage	PARP1	hsa142
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
Result	These results indicate that furanodiene may be a promising and safety natural agent for cancer adjuvant therapy in the future.

Pair Name	Furanodiene, Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Inhibition-->Cell metastasis
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Down-regulation	Expression	CTNNB1	hsa1499
	Down-regulation	Expression	ITGAV	hsa3685
	Down-regulation	Expression	MMP9	hsa4318
	Down-regulation	Phosphorylation	PIK3R1	hsa5295
	Down-regulation	Phosphorylation	PTK2	hsa5747
	Down-regulation	Phosphorylation	PXN	hsa5829
	Down-regulation	Phosphorylation	SRC	hsa6714
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
Result	These observations indicate that furanodiene is a potential agent that may be utilized to improve the anticancer efficacy of doxorubicin and overcome the risk of chemotherapy in highly metastatic breast cancer.